BOSENTAN FOR DUMMIES

6 The phosphodiesterase-five inhibitor sildenafil is certified for PAH in FC I–IV during the USA and FC II–III in Europe. Endothelin receptor antagonists (ERAs) like bosentan, sitaxentan and ambrisentan are oral therapies licensed for use in PAH. As no oral agent has revealed superiority there remains discussion as to which must be utilised ini